Guide Advances in Microbial Physiology: 62

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It is clear that microorganisms undergo profound changes during their transition from planktonic free-swimming organisms to cells that are part of a complex, Individual planktonic cells can form cell-to-surface and cel-to-cell contacts resulting in the formation of microcolonies. The hallmark architecture of the bio Within 30 minutes or less, a monolayer of bacteria forms on the abiotic surface. By 3—4 hours, this mono A wild-type and B type IV pili-defective mutant.

This image shows a top-down view o Both organisms form distinct aggregates of See text for an in-depth discussion of the similarities between these developmental pathways. Persisters are dormant variants of regular cells that form stochastically in microbial populations and are highly tolerant to antibiotics. High persister hip mutants of Pseudomonas aeruginosa are selected in patients with cystic fibrosis. Similarly, hip Figure 1: A test for persister heritability.

An exponentially growing culture of Escherichia coli was treated with a high dose of ampicillin at time 0.

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After lysis, surviving persisters were reinocula Figure 2: Resistance versus tolerance. Bactericidal antibiotics kill cells by forcing the active target to produce corrupted products. Streptomycin interrupts translation, producing toxic misfolded pe Figure 3: A model of a relapsing biofilm infections. Regular cells and persister cells form in the biofilm and are shed off into surrounding tissue and the bloodstream. Handbook of Whales, Dolphins and Porpoises.

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DOI: Droplet microfluidics for microbiology: techniques, applications and challenges T. Kaminski, O. Scheler and P. Search articles by author Tomasz S.

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